Detalhe da pesquisa
1.
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.
Cell
; 172(4): 731-743.e12, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425491
2.
A futile approach to fighting obesity?
Cell
; 163(3): 539-40, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26496598
3.
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
Nature
; 599(7884): 296-301, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34707293
4.
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
Proc Natl Acad Sci U S A
; 116(30): 15184-15193, 2019 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31289229
5.
Countering inflammatory signals in obesity.
Nat Immunol
; 15(5): 410-1, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24747704
6.
RalA controls glucose homeostasis by regulating glucose uptake in brown fat.
Proc Natl Acad Sci U S A
; 115(30): 7819-7824, 2018 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915037
7.
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.
Mol Pharmacol
; 94(4): 1210-1219, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30082428
8.
Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.
Bioorg Med Chem
; 26(20): 5443-5461, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30270002
9.
Adipsin and Adipocyte-derived C3aR1 Regulate Thermogenic Fat in a Sex-dependent Fashion.
JCI Insight
; 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38713526
10.
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Nat Metab
; 6(2): 273-289, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38286821
11.
Culture and Differentiation of Primary Preadipocytes from Mouse Subcutaneous White Adipose Tissue.
Methods Mol Biol
; 2662: 11-24, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37076667
12.
Measuring the Rate of Lipolysis in Ex vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro.
J Vis Exp
; (193)2023 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010285
13.
Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.
Diabetes
; 72(3): 367-374, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36449000
14.
Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation.
J Biol Chem
; 286(2): 1237-47, 2011 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21059653
15.
Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes.
Arthritis Res Ther
; 24(1): 175, 2022 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35879786
16.
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
J Clin Invest
; 131(10)2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822771
17.
Chop/Ddit3 depletion in ß cells alleviates ER stress and corrects hepatic steatosis in mice.
Sci Transl Med
; 13(604)2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34321322
18.
FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes.
Cell Rep
; 35(13): 109331, 2021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192547
19.
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.
Cell Metab
; 32(6): 1012-1027.e7, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33152322
20.
Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3.
Nat Metab
; 2(7): 620-634, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32694788